Genetic isolates: Separate but equal?

Commentary Genetic isolates: Separate but equal?

The tiny volcanic island of Tristan da Cunha is the most remote inhabited place on Earth. It lies in the South Atlantic, 1,700 miles and a week’s journey by boat from Cape Town, South Africa. The island’s population of 300 is descended from a handful of founders, mostly shipwreck survivors, who settled there in the 19th century. The small number of founders is reflected in the fact that only se...

Separate but not equal: differential mechanical roles for Myosin isoforms.

Cells undergo many structural-mechanical changes as an inextricable component of cellular motility, cytokinesis, and changes in cell shape. The mere act of receptor-mediated adhesion to extracellular matrix involves massive changes in cytoskeletal organization, spreading, and flattening of cells against the matrix, and the generation of traction forces through the contractile activity of cells....

Separate but not equal: the consequences of segregated health care.

Cardiovascular disease accounts for as much as one third of the differential in life expectancy between blacks and whites in the United States.1 A multifactorial process likely leads to these disparate outcomes (see the Figure), including differences in biology, differential awareness, knowledge, beliefs, and preferences for care for cardiovascular disease, and varying distribution of risk fact...

PTSD co-morbid with HIV: Separate but equal, or two parts of a whole?

Approximately 30 million people currently live with HIV worldwide and the incidence of stress-related disorders, such as post-traumatic stress disorder (PTSD), is elevated among people living with HIV as compared to those living without the virus. PTSD is a severely debilitating, stress-related psychiatric illness associated with trauma exposure. Patients with PTSD experience intrusive and fear...

Foreword: Separate but Equal: The Status of America's Public Schools Symposium